The San Francisco 49ers face the Los Angeles Rams at 1:25 p.m. PDT on Sunday, Sept. 22 at SoFi Stadium in Inglewood, CA.

After spending six seasons in red and gold, the former 49ers quarterback will be on the opposing sideline on Sunday in Los Angeles.

Fresh off a blowout win over the Rams, the Cardinals will host the Lions in Week 3 with a chance to be a team to be taken ...

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The San Francisco 49ers face the Los Angeles Rams at 1:25 p.m. PDT on Sunday, Sept. 22 at SoFi Stadium in Inglewood, CA.

There may not be two teams more injured than the Los Angeles Rams and San Francisco 49ers, which will have a big impact on ...

Also likely to be out is tight end George Kittle, who is doubtful and battling a hamstring issue. That will further ding the ...

The 49ers are dealing with a long list of injuries and no one would argue that's where the team wants to find itself as they ...

With nine 0-2 NFL teams entering "must-win" week, bettors are mixed on which squads will avoid a third consecutive loss.

Has it been the year of the underdog in the NFL? Not only were there a ton of upsets in Week 2 of the 2024 NFL season, but underdogs of six points or more went ...

The injury report for the 49ers looks particularly concerning. Running back Christian McCaffrey, the 2024 NFL Offensive ...

Former Illini Devon Witherspoon is off to a successful start in his second NFL season and has helped the Seattle Seahawks win ...